Axon and Schwann Cell Partnership During Nerve Regrowth
نویسندگان
چکیده
منابع مشابه
Schwann Cell and Axon Electrical Potential Differences
In fifty-seven resting nerve fibers of the squid Sepioteuthis sepioidea impaled from outside to inside, three potential difference (PD) levels were recorded. In twelve nerve fibers the position of the tip of the micropipette, when it was recording one of the PD levels, was labeled with carmine, and the minute spot of dye was localized histologically. The first PD level of -10 to -26 mv, was loc...
متن کاملSodium, Potassium, and Chloride Concentrations in the Schwann Cell and Axon of the Squid Nerve Fiber
Sodium, potassium, and chloride concentrations were determined in the sheath cells and axoplasm of the nerve fiber of the squid Sepioteuthis sepioidea. The sheaths were obtained by slitting the nerve fiber, the extracellular electrolytes were washed out in isotonic sucrose solution, and the concentrations in the cells were determined after different soaking times in the sucrose solution. Values...
متن کاملTissue culture observations relevant to the study of axon-Schwann cell interactions during peripheral nerve development and repair.
During peripheral nerve development the Schwann cell population is expanded so that adequate numbers are available for ensheathment of both nonmyelinated and myelinated nerve fibres. As ensheathment of these fibres progresses each axon--Schwann cell unit becomes surrounded by a basal lamina, providing a unique microtubular framework within the peripheral nerve trunk. Tissue culture studies of p...
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Laminins are heterotrimeric extracellular matrix proteins that regulate cell viability and function. Laminin-2, composed of alpha2, beta1, and gamma1 chains, is a major matrix component of the peripheral nervous system (PNS). To investigate the role of laminin in the PNS, we used the Cre-loxP system to disrupt the laminin gamma1 gene in Schwann cells. These mice have dramatically reduced expres...
متن کاملCdc2-mediated Schwann cell migration during peripheral nerve regeneration.
Schwann cell migration facilitates peripheral nerve regeneration after injury. We have recently found increased activation of Cdc2 kinase in regenerating sciatic nerves. Here we show that Cdc2 phosphorylation of caldesmon regulates Schwann cell migration and nerve regeneration. A robust but transient increase in Cdc2 expression was found in cultured Schwann cells prepared from the sciatic nerve...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2005
ISSN: 0022-3069
DOI: 10.1097/01.jnen.0000171650.94341.46